Preparation of eugenol and albumin.



UNITED STATES PATENT OFFICE.

.H'ANS BELART,,OF HUDDERSFIELD, ENGLAND.

PREPARATION OF EUGENOL AND. ALBUMIN.

No Drawing.

Specification of Letters Patent.

Application filed May 8, 1908. Serial No. 431,698. (Specimens) Patented Oct. 25, 1910.

To'all whom it may concern:

Be it known that I, I'IANS BELAn'r, a citizen of Switzerland, residing at' Huddersfield, in the county of York, Kingdom of Great. Britain, have invented new and useful Improvements in Preparations of Eugenol and Albumin, of which the following is a specification.

In treating tuberculous diseases, hitherto the disinfecting phenols used besides creosote, have been mainly guaiacol, either by itself or in its compounds, for instance carbonate or thiocol, as other phenols such as cresol and xylenol, could not be used owing to their caustic and artly direct oisonous action. Creosote and guaiacol be ore being used, were either mixed with milk or according to the cation of Englis Letters Patent granted to H. C. Fehrlin, No. 449 of 1904, guaiacol or guaethol were-formed into indigestible egg albumin compounds. These compounds are also not free from the-guaiacol-tar odor so disagreeable to patients. While the other phenol albumin compounds such as carbolic I acid and cresol, xylenol havebeen found undiseases.

pectcd a priori. The new compoundsare produced in the usable, owing to their caustic and poisonous action becoming evident again in'being split up by the mucus in the bowels,-it has been found, that eugenol and isoeu enol or oil of cloves consisting as is wellcnown rincipully of eugenol, combined withal uminsuch as for instance albumin of eggs and casein, give compounds which resemble those of guaiaool and other cal composition but which are distinguished by their eminent therapeutic properties,- articularly in the treatmentof tubercu ous Having a rapid healing effect, they possess neither the poisonous subsidi ury properties of other phenols nor the disagreeab e tar-odor ofthe guaiacol or guaethol and are not only disinfectin owing to their henol character but have a so a soothin s ee -inducing and cough-stoppin effeiiti, as In the human body a part 0% the eugenol and still more of the isoeu enol will observform into vanillin which is clear able from the odor of the urine. his conspicuously favorable effect could not be ex -ff' rocess described in sp'ecifi henols in their chemi- SHIHGIIHHHIIBI as other phenol albumin compounds.

Thechemical reaction which takes place may be illustrated by the following equation.

-rz nz ia 22+ e a s a 5= parts of caustic alkali and added to a solution of 1,600 parts albumin of eggs and 10,000 parts of water. This solution is poured into 54 parts of sulfuric acid and 500 parts of water by constant stirring. The mixture is then heated until boilin the white coagulum formed' is filtered'o, washed with hot water, ressed, washed again with hot water and nall with alcohol. .The product is then dried andfora few hours sub'ected to a heat of 115420 centigrade. T e body thus obtained is an orange yellowpowder in smell slightly like oil 0 cloves and is insoluble in water or diluted acid.

I claim:

1. A process ,for the production of a compound of eugenol and albumin, consistin in mixing a watery alkaline solution go eugenol. with a watery. solution of albumin,

iso ting, washing, and drying the reaction product formed, and rendering it indiestible in the stomach subjecting it'to' 3,

eat of 115-120 centigrade, substantially as and for the purpose. set forth.

2. As a new product, a compound for internal use, com osed of en enol and albuorm of a yeIlow powder, -in-- soluble in "water-and diluted acids, easily splitting up into its two components euge:

nol and albumin by the action of alkalies oi the alkaline action of the mucus of the bowels, substantially as set forth. 4

In testimony whereof Ihave signed my J name to this specification in. the presence of two subscribing witnesses.

HANS

BELART.

Witnesses.

.Anrnnn Bosslmnn'r, Stunner E. 'BBAMALL. 

